Researchers from Georg-August University Göttingen Germany have completed the genomic sequence of
P. alvei isolate DSM 29
(6.83Mb) This is an aerobic, Gram-positive bacteria that is often associated with
Melissococcus plutonius, the bacterial causative agent of European foul brood disease in honey bees.
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| Paenibacillus alvei are the larger, elongated bacteria. Melissococcus plutonius bacteria are clustered in the center. Photo from the USDA/ARS. |
Along with
P. alvei, a number of other bacteria also seem to associate frequently with
M. plutonius infections including
Brevibacillus laterosporus and
Enterococcus faecalis. Of note from the genome are a number of chitinase genes (10) and a hyaluronate lyase homolog, each of which may be virulence factors involved in host cell invasion. Also, a unique antimicrobial gene and several encoded toxin molecules (binary, mosquitocidal, alveolysin, insecticidal toxin complex) were identified. 454 GS-FLX with Titanium XL was used to sequence paired-end and shotgun DNA libraries, assembled to 18x coverage in 25 contigs. The genome contains approximately 6,605 coding genes.
A link to the paper in the Journal of Bacteriology is here:
P. alvei genome by Djukic, Becker, Poehlein, Voget, and Daniel
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